Information

Do HEK293T cells express sufficient endogenous G-Proteins for calcium imaging?


I want to transfect different GPCRs to HEK cells and then do calcium imaging. I was wondering if the endogenous expression levels of Gq are high enough.


RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No. 13/499,313, filed Aug. 13, 2012, which is a §371 national stage application based on Patent Cooperation Treaty Application serial number PCT/US2010/050960, filed Sep. 30, 2010, which claims the benefit of priority to U.S. Provisional Patent Application Ser. No. 61/247,251, filed Sep. 30, 2009 and U.S. Provisional Patent Application Ser. No. 61/247,309 filed Sep. 30, 2009 the contents of each of which are hereby incorporated by reference.


Research

Research interests

Dr Eggleton&lsquos research interest focuses on the understanding of innate and adaptive immunity in the pathology of autoimmune disease (systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis) and more recently, cancer, with a special interest in the role of endoplasmic reticulum chaperone proteins (calreticulin/calnexin).

Dr Eggleton has made important contributions to medical research through his research in characterizing the immune function of the collectin molecules (SP-A and SP-D) and complement proteins (e.g. C1q). He contributed to the discovery of the lectin pathway of complement activation, which has had far reaching implications as to how human immunity deals with microbial infections. He is also known for his work shown that endoplasmic reticulum (ER) chaperones &ndash e.g. calreticulin have extracellular immune modulating functions. This has led to a whole new avenue of research into the role of calreticulin in the cell death of cancers and the ability of parasites to avoid immune detection. His recent work has contributed to the discovery of a subset of CD20+, T-lymphocytes that appear to have a role in many human pathological processes. In addition, his work on post-translational modification of host proteins by oxidative stress and epigenetic/microbial influences has provided insight as to how autoantibodies are generated in autoimmune disease as well explaining how such autoantibodies are implicated in both pathology and as early diagnostic markers of disease of both systemic lupus erythematosus and rheumatoid arthritis.

Research projects

  • Development of cancer immunotherapeutics (Eggleton, Bremer and Michalak)
  • Extracellular role of calreticulin in immunity (Eggleton, Bremer and Michalak)
  • T cell pathology in MS (Eggleton, Bremer, Engelhardt, Gutowski and Michalak)
  • Triggers of rheumatoid arthritis (Eggleton, Hutchinson, Perry and Murphy)
  • Development of new medicines (UCB Pharma)

Research networks

Current staff - Exeter

  1. Dr Miranda Smallwood - Neuroinflammation (2010-12 and 2017-2019)
  2. Dr Trefa Abdullah (PhD student - Exeter) Investigation into the immune promoting mechanisms of calreticulin for targeted cancer cell death and immunotherapy. Funded by: Higher Committee for Education Development in Iraq. (2015-19)
  3. Dr Daniel Murphy (MD student &ndash Exeter) (2016-18) Investigation into cadmium-induced citrullinated protein production as a driver of systemic inflammation in rheumatoid arthritis
  4. Dr Janet Holley (Research associate and consultant neuroscientist) Immune pathology of multiple sclerosis (2014-2018)
  5. Alexander Clark (Research Assistant and PhD student) Lung disease and autoimmunity(2015-2019)
  6. Dr Lucy Moore - Hon Research Fellow Hyperbaric oxygen as a treatment for multiple sclerosis (2017-20)

Research grants

  • 2016Cornwall Arthritis Trust.
    Money for part funding of PhD studentship
  • 2014Cornwall Arthritis Trust.
    Genotyping of rheumatoid arthritis patients for risk alleles
  • 2014HCED in Iraq PhD Studentship
    Investigation into the immune promoting mechanisms of calreticulin for targeted cancer cell death and Immunotherapy
  • 2014Northcott Devon Medical Foundation
    Consumables for rheumatoid arthritis research
  • 2014Royal Devon & Exeter Foundation Trust
    Multiple Sclerosis research grant
  • 2012Alberta Innovates Health Solution
    Travel Fellowship
  • 2012Marie Curie Fellowship
    Characterization of CD20+ T-cells in healthy volunteers, ovarian cancer patients and patients with rheumatoid arthritis
  • 0Multiple Sclerosis Society
    The role of calnexin in T-cell trafficking across the blood-brain barrier in vitro and in vivo
  • 0Medical Research Council
    Development of novel bi-specific antibody-based fusion proteins to inhibit and kill autoreactive T-cells prior to them crossing the blood brain barrier
  • 0Alberta Innovates Health Solution
    Exploring the multi-functional anti-tumor activity of calreticulin for targeted ovarian cancer therapy
  • 0Alberta Innovates Health Solution
    Design of a new immune boosting strategy for ovarian cancer
  • 0Horizon 2020 Innovative Training Networks (ITN)
    Innovative Training Networks (ITN) Call: H2020-MSCA-ITN-2015 Entitled: An Integrated Network for Exploitation of the Central Role of the Endoplasmic Reticulum for immunotherapy of human disease
  • 0European Research Council
    European research Council award for Professor Michalak (University of Alberta) and Dr Eggleton to conduct international neurology research
  • 0Arthritis Research UK
    ARUK PhD studentship

FIGURE DESCRIPTIONS

FIG. 1 shows exemplary calcium entry-mediated events in immune cells. For example, as depicted, receptor activation leads to depletion of ER calcium stores, which activates capacitative calcium entry through Icrac channels. Calcium entry activates calmodulin-dependent enzymes including the serine phosphatase calcineurin, which leads to release of inflammatory mediators in mast cells. Activation of calcineurin also leads to dephosphorylation, nuclear translocation and activation of transcription factors such as NFAT. NFAT activation results in expression and release of cytokines and T cell proliferation. Abbreviations: CCE, calcium capacitative entry ICRAC, calcium release activated calcium channel current PLCγ, phospholipase C gamma IP3, Inositol 1,4,5-triphosphate SERCA, sarcoplasmic/endoplasmic reticulum calciumATPase DAG, diacyl glycerol ER, endoplasmic reticulum CaM, Calmodulin NFAT, nuclear factor of activated T cells.

FIG. 2 is a graph showing fluorescence vs. time as measured in HEK293 cells which had been loaded with a fluorescent indicator and subjected to conditions designed to assess store-operated calcium entry into the cell (see EXAMPLES for details of the methods). The curve labeled as “STIM1” reflects fluorescence levels in a cell in which STIM1 protein and mRNA expression had been reduced to non-detectable levels using siRNA-based interference methods described herein. The curve labeled “Control” reflects fluorescence levels in a cell that had been treated with control RNAs as described herein. At time “0”, 1 μM thapsigargin was added to the essentially calcium-free medium. The increase in fluorescence upon addition of thapsigargin reflects an increase (followed by decrease) in calcium levels in the cytosol due to release of calcium from intracellular calcium stores. At about 16 minutes, 1.8 mM calcium was added to the medium. The increase in fluorescence upon addition of calcium to the medium reflects store-operated calcium entry into the cytosol.

FIG. 3 is a graph showing fluorescence vs. time as measured in HEK293 cells which had been loaded with a fluorescent indicator and subjected to conditions designed to assess store-operated calcium entry into the cell (see EXAMPLES for details of the methods). The curve labeled as “STIM1” reflects fluorescence levels in a cell in which STIM1 protein and mRNA expression had been reduced to non-detectable levels using siRNA-based interference methods described herein. The curve labeled “Control” reflects fluorescence levels in a cell that had been treated with control RNAs as described herein. At time “0”, 300 μM methylcholine was added to the essentially calcium-free medium. The increase in fluorescence upon addition of thapsigargin reflects an increase (followed by decrease) in calcium levels in the cytosol due to release of calcium from intracellular calcium stores. At about 5 minutes, 1.8 mM calcium was added to the medium. The increase in fluorescence upon addition of calcium to the medium reflects calcium influx into the cell that includes store-operated calcium entry.

FIG. 4 is a graph showing fluorescence vs. time as measured in HEK293 cells which had been loaded with a fluorescent indicator and subjected to conditions designed to assess store-operated calcium entry (SOCE) into the cell (see EXAMPLES for details of the methods). The curves labeled as “STIM1” (dotted line) reflects fluorescence levels in a cell overexpressing STIM1 (HEK[STIM1]). The curves labeled “Control” (solid line) reflect fluorescence levels in a control HEK293 cell. At time “0”, either DMSO (Panel A) or 1 μM thapsigargin (Panel B) was added to the essentially calcium-free medium. At about 15 minutes, 1.8 mM calcium was added to the medium. Overexpression of STIM1 results in constitutive activation of Ca 2+ entry, enhanced thapsigargin-activated Ca 2+ entry, and a reduction in the amplitude and kinetics of the thapsigargin-mediated release of calcium from the internal stores.


Terrence Sejnowski

Nakahira, Y., Liu, Q., Sejnowski, T.J. , Doyle, J.C. Diversity-enabled sweet spots in layered architectures and speed-accuracy trade-offs in sensorimotor control. (2021) Proceedings of the National Academy of Sciences of the United States of America. 118(22). DOI: 10.1073/pnas.1916367118

Compans, B., Camus, C., Kallergi, E., Sposini, S., Martineau, M., Butler, C., Kechkar, A., Klaassen, R.V., Retailleau, N., Sejnowski, T.J. , Smit, A.B., Sibarita, J.B., Bartol, T.M., Perrais, D., Nikoletopoulou, V., Choquet, D., Hosy, E. NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95. (2021) Nature Communications. 12(1):2849. DOI: 10.1038/s41467-021-23133-9

Singh, N., Bartol, T., Levine, H., Sejnowski, T. , Nadkarni, S. Presynaptic endoplasmic reticulum regulates short-term plasticity in hippocampal synapses. (2021) Communications Biology. 4(1):241. DOI: 10.1038/s42003-021-01761-7

Trujillo, C.A., Adams, J.W., Negraes, P.D., Carromeu, C., Tejwani, L., Acab, A., Tsuda, B., Thomas, C.A., Sodhi, N., Fichter, K.M., Romero, S., Zanella, F., Sejnowski, T.J. , Ulrich, H., Muotri, A.R. Pharmacological reversal of synaptic and network pathology in human MECP2-KO neurons and cortical organoids. (2021) EMBO Molecular Medicine. 13(1):e12523. DOI: 10.15252/emmm.202012523

Tsuda, B., Tye, K.M., Siegelmann, H.T., Sejnowski, T.J. A modeling framework for adaptive lifelong learning with transfer and savings through gating in the prefrontal cortex. (2020) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.2009591117

Davis, W., Muller, L., Martinez-Trujillo, J., Sejnowski, T. , Reynolds, J.H. Spontaneous travelling cortical waves gate perception in behaving primates (2020) Nature. DOI: https://www.nature.com/articles/s41586-020-2802-y.

Sejnowski, T. Charles Gross: Mentor, Maestro, Mensch. (2020) Progress in Neurobiology.:101926 DOI: 10.1016/j.pneurobio.2020.101926

Gonzalez, C.E., Lainscsek, C., Sejnowski, T.J. , Letellier, C. Assessing observability of chaotic systems using Delay Differential Analysis. (2020) Chaos. 30(10):103113. DOI: 10.1063/5.0015533

Lin, T.W., Chen, Y., Bukhari, Q., Krishnan, G.P., Bazhenov, M., Sejnowski, T.J. Differential Covariance: A New Method to Estimate Functional Connectivity in fMRI. (2020) Neural Computation.:1-33 DOI: 10.1162/neco_a_01323

Ordyan, M., Bartol, T., Kennedy, M., Rangamani, P., Sejnowski, T. Interactions between calmodulin and neurogranin govern the dynamics of CaMKII as a leaky integrator. (2020) PLOS Computational Biology. 16(7):e1008015. DOI: 10.1371/journal.pcbi.1008015

Goncalves, J., Bartol, T.M., Camus, C., Levet, F., Menegolla, A.P., Sejnowski, T.J. , Sibarita, J.B., Vivaudou, M., Choquet, D., Hosy, E. Nanoscale co-organization and coactivation of AMPAR, NMDAR, and mGluR at excitatory synapses. (2020) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1922563117

Filimon, F., Nelson, J.D., Sejnowski, T.J. , Sereno, M.I., Cottrell, G.W. The ventral striatum dissociates information expectation, reward anticipation, and reward receipt. (2020) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1911778117

DAS, A., Cash, S.S., Sejnowski, T.J. Heterogeneity of Preictal Dynamics in Human Epileptic Seizures. (2020) IEEE Access. 8:52738-52748. DOI: 10.1109/access.2020.2981017

Sejnowski, T.J. The unreasonable effectiveness of deep learning in artificial intelligence. (2020) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1907373117

Garcia, G.C., Bartol, T.M., Phan, S., Bushong, E.A., Perkins, G., Sejnowski, T.J. , Ellisman, M.H., Skupin, A. Mitochondrial morphology provides a mechanism for energy buffering at synapses. (2019) Scientific Reports. 9(1):18306. DOI: 10.1038/s41598-019-54159-1

Jullié, D., Stoeber, M., Sibarita, J.B., Zieger, H.L., Bartol, T.M., Arttamangkul, S., Sejnowski, T.J. , Hosy, E., von Zastrow, M. A Discrete Presynaptic Vesicle Cycle for Neuromodulator Receptors. (2019) Neuron. DOI: 10.1016/j.neuron.2019.11.016

Pharris, M.C., Patel, N.M., VanDyk, T.G., Bartol, T.M., Sejnowski, T.J. , Kennedy, M.B., Stefan, M.I., Kinzer-Ursem, T.L. A Multi-State Model of the CaMKII Dodecamer Suggests a Role for Calmodulin in Maintenance of Autophosphorylation. (2019) PLOS Computational Biology. 15(12):e1006941. DOI: 10.1371/journal.pcbi.1006941

Lainscsek, C., Rungratsameetaweemana, N., Cash, S.S., Sejnowski, T.J. Cortical chimera states predict epileptic seizures. (2019) Chaos. 29(12):121106. DOI: 10.1063/1.5139654

Ruiz-Martínez, , Bartol, T.M., Sejnowski, T.J. , Tartakovsky, D.M. Stochastic self-tuning hybrid algorithm for reaction-diffusion systems. (2019) Journal of Chemical Physics. 151(24):244117. DOI: 10.1063/1.5125022

Siddharth, S., Jung, T.P., Sejnowski, T.J. Impact of Affective Multimedia Content on the Electroencephalogram and Facial Expressions. (2019) Scientific Reports. 9(1):16295. DOI: 10.1038/s41598-019-52891-2

De la Fuente, I.M., Bringas, C., Malaina, I., Regner, B., Pérez-Samartín, A., Boyano, M.D., Fedetz, M., López, J.I., Pérez-Yarza, G., Cortes, J.M., Sejnowski, T. The nucleus does not significantly affect the migratory trajectories of amoeba in two-dimensional environments. (2019) Scientific Reports. 9(1):16369. DOI: 10.1038/s41598-019-52716-2

Litvina, E., Adams, A., Barth, A., Bruchez, M., Carson, J., Chung, J.E., Dupre, K.B., Frank, L.M., Gates, K.M., Harris, K.M., Joo, H., William Lichtman, J., Ramos, K.M., Sejnowski, T. , Trimmer, J.S., White, S., Koroshetz, W. BRAIN Initiative: Cutting-Edge Tools and Resources for the Community. (2019) Journal of Neuroscience. 39(42):8275-8284. DOI: 10.1523/JNEUROSCI.1169-19.2019

Kim, R., Li, Y., Sejnowski, T.J. Simple framework for constructing functional spiking recurrent neural networks. (2019) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1905926116

Cugno, A., Bartol, T.M., Sejnowski, T.J. , Iyengar, R., Rangamani, P. Geometric principles of second messenger dynamics in dendritic spines. (2019) Scientific Reports. 9(1):11676. DOI: 10.1038/s41598-019-48028-0

Wang, H.P., Garcia, J.W., Sabottke, C.F., Spencer, D., Sejnowski, T.J. Feedforward thalamocortical connectivity preserves stimulus timing information in sensory pathways. (2019) Journal of Neuroscience. DOI: 10.1523/JNEUROSCI.3165-17.2019

Pinto-Duarte, A., Roberts, A.J., Ouyang, K., Sejnowski, T.J. Impairments in remote memory caused by the lack of Type 2 IP receptors. (2019) Glia. DOI: 10.1002/glia.23679

Zhou, J., Ma, J., Chen, Y., Cheng, C., Bao, B., Peng, J., Sejnowski, T.J. , Dixon, J.R., Ecker, J.R. Robust single-cell Hi-C clustering by convolution- and random-walk-based imputation. (2019) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1901423116

Oakley, B.A., Sejnowski, T.J. What we learned from creating one of the world's most popular MOOCs. (2019) NPJ Sci Learn. 4:7. DOI: 10.1038/s41539-019-0046-0

Ernst, O.K., Bartol, T.M., Sejnowski, T.J. , Mjolsness, E. Learning moment closure in reaction-diffusion systems with spatial dynamic Boltzmann distributions. (2019) Phys Rev E. 99(6-1):063315. DOI: 10.1103/PhysRevE.99.063315

Siddharth, Patel, A.N., Jung, T.P., Sejnowski, T.J. A Wearable Multi-Modal Bio-Sensing System Towards Real-World Applications. (2019) IEEE Trans Biomed Eng. 66(4):1137-1147. DOI: 10.1109/TBME.2018.2868759

Tapia, J.J., Saglam, A.S., Czech, J., Kuczewski, R., Bartol, T.M., Sejnowski, T.J. , Faeder, J.R. MCell-R: A Particle-Resolution Network-Free Spatial Modeling Framework. (2019) Methods in Molecular Biology. 1945:203-229. DOI: 10.1007/978-1-4939-9102-0_9

Aimon, S., Katsuki, T., Jia, T., Grosenick, L., Broxton, M., Deisseroth, K., Sejnowski, T.J. , Greenspan, R.J. Fast near-whole-brain imaging in adult Drosophila during responses to stimuli and behavior. (2019) PLOS Biology. 17(2):e2006732. DOI: 10.1371/journal.pbio.2006732

Lainscsek, C., Sampson, A.L., Kim, R., Thomas, M.L., Man, K., Lainscsek, X., , Swerdlow, N.R., Braff, D.L., Sejnowski, T.J. , Light, G.A. Nonlinear dynamics underlying sensory processing dysfunction in schizophrenia. (2019) Proceedings of the National Academy of Sciences of the United States of America. 116(9):3847-3852. DOI: 10.1073/pnas.1810572116

Padmanabhan, K., Osakada, F., Tarabrina, A., Kizer, E., Callaway, E.M., Gage, F.H., Sejnowski, T.J. Centrifugal Inputs to the Main Olfactory Bulb Revealed Through Whole Brain Circuit-Mapping. (2019) Frontiers in Neuroanatomy. 12:115. DOI: 10.3389/fnana.2018.00115

Sampson, A.L., Lainscsek, C., Gonzalez, C.E., Ulbert, I., Devinsky, O., Fabó, D., Halgren, E., Cash, S.S., Sejnowski, T.J. Delay Differential Analysis for Dynamical Sleep Spindle Detection. (2019) Journal of Neuroscience Methods. DOI: 10.1016/j.jneumeth.2019.01.009

Reddy, G., Wong-Ng, J., Celani, A., Sejnowski, T.J. , Vergassola, M. Glider soaring via reinforcement learning in the field. (2018) Nature. DOI: 10.1038/s41586-018-0533-0

Sejnowski, T. The prophet who foretold our future. (2018) Brain : A Journal of Neurology. 141(9):2820-2822. DOI: 10.1093/brain/awy212

Ernst, O.K., Bartol, T., Sejnowski, T. , Mjolsness, E. Learning dynamic Boltzmann distributions as reduced models of spatial chemical kinetics. (2018) J Chem Phys. 149(3):034107. DOI: 10.1063/1.5026403

Haas, K.T., Compans, B., Letellier, M., Bartol, T.M., Grillo-Bosch, D., Sejnowski, T.J. , Sainlos, M., Choquet, D., Thoumine, O., Hosy, E. Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency. (2018) Elife. 7. DOI: 10.7554/eLife.31755

100nm lateral shift between AMPAR nanoclusters and glutamate release sites induces a significant reduction in AMPAR-mediated currents. Thus, our results suggest the synapses necessity to release glutamate precisely in front of AMPAR nanodomains, to maintain a high synaptic responses efficiency.

Siddharth, Jung, T.P., Sejnowski, T.J. Multi-modal Approach for Affective Computing. (2018) Conf Proc IEEE Eng Med Biol Soc. 2018:291-294. DOI: 10.1109/EMBC.2018.8512320

Krishnan, G.P., Rosen, B.Q., Chen, J.Y., Muller, L., Sejnowski, T.J. , Cash, S.S., Halgren, E., Bazhenov, M. Thalamocortical and intracortical laminar connectivity determines sleep spindle properties. (2018) PLOS Computational Biology. 14(6):e1006171. DOI: 10.1371/journal.pcbi.1006171

Ruiz-Martínez, , Bartol, T.M., Sejnowski, T.J. , Tartakovsky, D.M. Efficient models of polymerization applied to FtsZ ring assembly in . (2018) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1719391115

Moldakarimov, S., Bazhenov, M., Feldman, D.E., Sejnowski, T.J. Structured networks support sparse traveling waves in rodent somatosensory cortex. (2018) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1710202115

Wang, X., Pinto-Duarte, A., Behrens, M.M., Zhou, X., Sejnowski, T.J. Ketamine independently modulated power and phase-coupling of theta oscillations in Sp4 hypomorphic mice. (2018) PLOS One. 13(3):e0193446. DOI: 10.1371/journal.pone.0193446

Muller, L., Chavane, F., Reynolds, J., Sejnowski, T.J. Cortical travelling waves: mechanisms and computational principles. (2018) Nature Reviews. Neuroscience. DOI: 10.1038/nrn.2018.20

Kaya, C., Cheng, M.H., Block, E.R., Bartol, T.M., Sejnowski, T.J. , Sorkin, A., Faeder, J.R., Bahar, I. Heterogeneities in Axonal Structure and Transporter Distribution Lower Dopamine Reuptake Efficiency. (2018) eNeuro. 5(1). DOI: 10.1523/ENEURO.0298-17.2017

Bromer, C., Bartol, T.M., Bowden, J.B., Hubbard, D.D., Hanka, D.C., Gonzalez, P.V., Kuwajima, M., Mendenhall, J.M., Parker, P.H., Abraham, W.C., Sejnowski, T.J. , Harris, K.M. Long-term potentiation expands information content of hippocampal dentate gyrus synapses. (2018) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1716189115

Wang, M., He, Y., Sejnowski, T.J. , Yu, X. Brain-state dependent astrocytic Ca2+ signals are coupled to both positive and negative BOLD-fMRI signals. (2018) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1711692115

Holter, K.E., Kehlet, B., Devor, A., Sejnowski, T.J. , Dale, A.M., Omholt, S.W., Ottersen, O.P., Nagelhus, E.A., Mardal, K.A., Pettersen, K.H. Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow. (2017) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1706942114

Luo, C., Keown, C.L., Kurihara, L., Zhou, J., He, Y., Li, J., Castanon, R., Lucero, J., Nery, J.R., Sandoval, J.P., Bui, B., Sejnowski, T.J. , Harkins, T.T., Mukamel, E.A.*, Behrens, M.M.*, Ecker, J.R.* Single-cell methylomes identify neuronal subtypes and regulatory elements in mammalian cortex. (2017) Science. 357(6351):600-604. DOI: 10.1126/science.aan3351

Lainscsek, C., Weyhenmeyer, J., Cash, S.S., Sejnowski, T.J. Delay Differential Analysis of Seizures in Multichannel Electrocorticography Data. (2017) Neural Computation.:1-38 DOI: 10.1162/neco_a_01009

Lin, T.W., Das, A., Krishnan, G.P., Bazhenov, M., Sejnowski, T.J. Differential Covariance: A New Class of Methods to Estimate Sparse Connectivity from Neural Recordings. (2017) Neural Computation.:1-52 DOI: 10.1162/neco_a_01008

Veit, J., Hakim, R., Jadi, M.P., Sejnowski, T.J. , Adesnik, H. Cortical gamma band synchronization through somatostatin interneurons. (2017) Nature Neuroscience. 20(7):951-959. DOI: 10.1038/nn.4562

Hurtado-López, J., Ramirez-Moreno, D.F., Sejnowski, T.J. Decision-making neural circuits mediating social behaviors : An attractor network model. (2017) Journal of Computational Neuroscience. DOI: 10.1007/s10827-017-0654-8

Peterson, D.A., Sejnowski, T.J. A Dynamic Circuit Hypothesis for the Pathogenesis of Blepharospasm. (2017) Frontiers in Computational Neuroscience. 11:11. DOI: 10.3389/fncom.2017.00011

O'Donnell, C., Gonçalves, J.T., Whiteley, N., Portera-Cailliau, C., Sejnowski, T.J. The Population Tracking Model: A Simple, Scalable Statistical Model for Neural Population Data. (2017) Neural Computation. 29(1):50-93. DOI: 10.1162/NECO_a_00910

Peterson, D.A., Littlewort, G.C., Bartlett, M.S., Macerollo, A., Perlmutter, J.S., Jinnah, H.A., Hallett, M., Sejnowski, T.J. Objective, computerized video-based rating of blepharospasm severity. (2016) Neurology. 87(20):2146-2153. DOI: 10.1212/WNL.0000000000003336

Churchland, P.S., Sejnowski, T.J. Blending computational and experimental neuroscience. (2016) Nature Reviews. Neuroscience. 17(11):667-668. DOI: 10.1038/nrn.2016.114

Grillner, S., Ip, N., Koch, C., Koroshetz, W., Okano, H., Polachek, M., Poo, M.M., Sejnowski, T.J. Worldwide initiatives to advance brain research. (2016) Nature Neuroscience. 19(9):1118-22. DOI: 10.1038/nn.4371

Kosik, K.S., Sejnowski, T.J. , Raichle, M.E., Ciechanover, A., Baltimore, D. A path toward understanding neurodegeneration. (2016) Science. 353(6302):872-3. DOI: 10.1126/science.aai7622

Reddy, G., Celani, A., Sejnowski, T.J. , Vergassola, M. Learning to soar in turbulent environments. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(33):E4877-84. DOI: 10.1073/pnas.1606075113

Huh, D., Sejnowski, T.J. Conservation law for self-paced movements. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(31):8831-6. DOI: 10.1073/pnas.1608724113

Padmanabhan, K., Osakada, F., Tarabrina, A., Kizer, E., Callaway, E.M., Gage, F.H., Sejnowski, T.J. Diverse Representations of Olfactory Information in Centrifugal Feedback Projections. (2016) Journal of Neuroscience. 36(28):7535-45. DOI: 10.1523/JNEUROSCI.3358-15.2016

Ruiz-Martinez, A., Bartol, T.M., Sejnowski, T.J. , Tartakovsky, D.M. Efficient Multiscale Models of Polymer Assembly. (2016) Biophysical Journal. 111(1):185-96. DOI: 10.1016/j.bpj.2016.05.022

Saremi, S., Sejnowski, T.J. Correlated Percolation, Fractal Structures, and Scale-Invariant Distribution of Clusters in Natural Images. (2016) IEEE Trans Pattern Anal Mach Intell. 38(5):1016-20. DOI: 10.1109/TPAMI.2015.2481402

Rodrigues, S., Desroches, M., Krupa, M., Cortes, J.M., Sejnowski, T.J. , Ali, A.B. Time-coded neurotransmitter release at excitatory and inhibitory synapses. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(8):E1108-15. DOI: 10.1073/pnas.1525591113

O'Donnell, C., Sejnowski, T.J. Street View of the Cognitive Map. (2016) Cell. 164(1-2):13-5. DOI: 10.1016/j.cell.2015.12.051

Bartol, T.M., Bromer, C., Kinney, J., Chirillo, M.A., Bourne, J.N., Harris, K.M., Sejnowski, T.J. Nanoconnectomic upper bound on the variability of synaptic plasticity. (2015) Elife. 4:e10778. DOI: 10.7554/eLife.10778

Bartol, T.M., Keller, D.X., Kinney, J.P., Bajaj, C.L., Harris, K.M., Sejnowski, T.J. , Kennedy, M.B. Computational reconstitution of spine calcium transients from individual proteins. (2015) Front Synaptic Neurosci. 7:17. DOI: 10.3389/fnsyn.2015.00017

Barnes, S.A., Pinto-Duarte, A., Kappe, A., Zembrzycki, A., Metzler, A., Mukamel, E.A., Lucero, J., Wang, X., Sejnowski, T.J. , Markou, A.*, Behrens, M.M.* Disruption of mGluR5 in parvalbumin-positive interneurons induces core features of neurodevelopmental disorders. (2015) Molecular Psychiatry. 20(10):1161-72. DOI: 10.1038/mp.2015.113

González, O.C., Krishnan, G.P., Chauvette, S., Timofeev, I., Sejnowski, T. , Bazhenov, M. Modeling of Age-Dependent Epileptogenesis by Differential Homeostatic Synaptic Scaling. (2015) Journal of Neuroscience. 35(39):13448-62. DOI: 10.1523/JNEUROSCI.5038-14.2015

Huh, D., Sejnowski, T.J. Spectrum of power laws for curved hand movements. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(29):E3950-8. DOI: 10.1073/pnas.1510208112

Schultz, M.D., He, Y., Whitaker, J.W., Hariharan, M., Mukamel, E.A., Leung, D., Rajagopal, N., Nery, J.R., Urich, M.A., Chen, H., Lin, S., Lin, Y., Jung, I., Schmitt, A.D., Selvaraj, S., Ren, B., Sejnowski, T.J. , Wang, W., Ecker, J.R. Human body epigenome maps reveal noncanonical DNA methylation variation. (2015) Nature. 523(7559):212-6. DOI: 10.1038/nature14465

Lainscsek, C., Weyhenmeyer, J., Sejnowski, T.J. , Letellier, C. Discovering independent parameters in complex dynamical systems. (2015) Chaos Solitons Fractals. 76:182-189. DOI: 10.1016/j.chaos.2015.04.001

Mo, A., Mukamel, E.A., Davis, F.P., Luo, C., Henry, G.L., Picard, S., Urich, M.A., Nery, J.R., Sejnowski, T.J. , Lister, R., Eddy, S.R., Ecker, J.R., Nathans, J. Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain. (2015) Neuron. 86(6):1369-84. DOI: 10.1016/j.neuron.2015.05.018

Sejnowski, T.J. Vernon Mountcastle: Father of neuroscience. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(21):6523-4. DOI: 10.1073/pnas.1506644112

Izpisua Belmonte, J.C., Callaway, E.M., Caddick, S.J., Churchland, P., Feng, G., Homanics, G.E., Lee, K.F., Leopold, D.A., Miller, C.T., Mitchell, J.F., Mitalipov, S., Moutri, A.R., Movshon, J.A., Okano, H., Reynolds, J.H., Ringach, D., Sejnowski, T.J. , Silva, A.C., Strick, P.L., Wu, J., Zhang, F. Brains, genes, and primates. (2015) Neuron. 86(3):617-31. DOI: 10.1016/j.neuron.2015.03.021

Jorgenson, L.A., Newsome, W.T., Anderson, D.J., Bargmann, C.I., Brown, E.N., Deisseroth, K., Donoghue, J.P., Hudson, K.L., Ling, G.S., MacLeish, P.R., Marder, E., Normann, R.A., Sanes, J.R., Schnitzer, M.J., Sejnowski, T.J. , Tank, D.W., Tsien, R.Y., Ugurbil, K., Wingfield, J.C. The BRAIN Initiative: developing technology to catalyse neuroscience discovery. (2015) Philos. Trans. R. Soc. Lond., B, Biol. Sci. 370(1668). DOI: 10.1098/rstb.2014.0164

Lainscsek, C., Sejnowski, T.J. Delay differential analysis of time series. (2015) Neural Computation. 27(3):594-614. DOI: 10.1162/NECO_a_00706

Lainscsek, C., Hernandez, M.E., Poizner, H., Sejnowski, T.J. Delay differential analysis of electroencephalographic data. (2015) Neural Computation. 27(3):615-27. DOI: 10.1162/NECO_a_00656

Moldakarimov, S., Bazhenov, M., Sejnowski, T.J. Feedback stabilizes propagation of synchronous spiking in cortical neural networks. (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(8):2545-50. DOI: 10.1073/pnas.1500643112

Frost, W.N., Brandon, C.J., Bruno, A.M., Humphries, M.D., Moore-Kochlacs, C., Sejnowski, T.J. , Wang, J., Hill, E.S. Monitoring Spiking Activity of Many Individual Neurons in Invertebrate Ganglia. (2015) Advances in Experimental Medicine and Biology. 859:127-45. DOI: 10.1007/978-3-319-17641-3_5

Sejnowski, T.J. Consciousness. (2015) Daedalus. 144(1):123-132. DOI: 10.1162/DAED_a_00321

Ritaccio, A., Brunner, P., Gunduz, A., Hermes, D., Hirsch, L.J., Jacobs, J., Kamada, K., Kastner, S., Knight, R.T., Lesser, R.P., Miller, K., Sejnowski, T. , Worrell, G., Schalk, G. Proceedings of the Fifth International Workshop on Advances in Electrocorticography. (2014) Epilepsy Behav. 41:183-92. DOI: 10.1016/j.yebeh.2014.09.015

Regner, B.M., Tartakovsky, D.M., Sejnowski, T.J. Identifying transport behavior of single-molecule trajectories. (2014) Biophysical Journal. 107(10):2345-51. DOI: 10.1016/j.bpj.2014.10.005

Sejnowski, T.J. , Churchland, P.S., Movshon, J.A. Putting big data to good use in neuroscience. (2014) Nature Neuroscience. 17(11):1440-1. DOI: 10.1038/nn.3839

Fields, R.D., Araque, A., Johansen-Berg, H., Lim, S.S., Lynch, G., Nave, K.A., Nedergaard, M., Perez, R., Sejnowski, T. , Wake, H. Glial biology in learning and cognition. (2014) The Neuroscientist. 20(5):426-31. DOI: 10.1177/1073858413504465

Mak-McCully, R.A., Deiss, S.R., Rosen, B.Q., Jung, K.Y., Sejnowski, T.J. , Bastuji, H., Rey, M., Cash, S.S., Bazhenov, M., Halgren, E. Synchronization of isolated downstates (K-complexes) may be caused by cortically-induced disruption of thalamic spindling. (2014) PLOS Computational Biology. 10(9):e1003855. DOI: 10.1371/journal.pcbi.1003855

Stefan, M.I., Bartol, T.M., Sejnowski, T.J. , Kennedy, M.B. Multi-state modeling of biomolecules. (2014) PLOS Computational Biology. 10(9):e1003844. DOI: 10.1371/journal.pcbi.1003844

Moldakarimov, S., Bazhenov, M., Sejnowski, T.J. Top-down inputs enhance orientation selectivity in neurons of the primary visual cortex during perceptual learning. (2014) PLOS Computational Biology. 10(8):e1003770. DOI: 10.1371/journal.pcbi.1003770

Lee, H.S., Ghetti, A., Pinto-Duarte, A., Wang, X., Dziewczapolski, G., Galimi, F., Huitron-Resendiz, S., Piña-Crespo, J.C., Roberts, A.J., Verma, I.M., Sejnowski, T.J. , Heinemann, S.F. Astrocytes contribute to gamma oscillations and recognition memory. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(32):E3343-52. DOI: 10.1073/pnas.1410893111

Weyhenmeyer, J., Hernandez, M.E., Lainscsek, C., Sejnowski, T.J. , Poizner, H. Muscle artifacts in single trial EEG data distinguish patients with Parkinson's disease from healthy individuals. (2014) Conf Proc IEEE Eng Med Biol Soc. 2014:3292-5. DOI: 10.1109/EMBC.2014.6944326

Broccard, F.D., Mullen, T., Chi, Y.M., Peterson, D., Iversen, J.R., Arnold, M., Kreutz-Delgado, K., Jung, T.P., Makeig, S., Poizner, H., Sejnowski, T. , Cauwenberghs, G. Closed-loop brain-machine-body interfaces for noninvasive rehabilitation of movement disorders. (2014) Ann Biomed Eng. 42(8):1573-93. DOI: 10.1007/s10439-014-1032-6

Saremi, S., Sejnowski, T.J. On criticality in high-dimensional data. (2014) Neural Computation. 26(7):1329-39. DOI: 10.1162/NECO_a_00607

Solstad, T., Yousif, H.N., Sejnowski, T.J. Place cell rate remapping by CA3 recurrent collaterals. (2014) PLOS Computational Biology. 10(6):e1003648. DOI: 10.1371/journal.pcbi.1003648

Sejnowski, T.J. Summary: Cognition in 2014. (2014) Cold Spring Harbor Symposia on Quantitative Biology. 79:237-41. DOI: 10.1101/sqb.2014.79.024885

Sejnowski, T.J. , Poizner, H., Lynch, G., Gepshtein, S., Greenspan, R.J. Prospective Optimization. (2014) Proceedings of the IEEE. Institute of Electrical and Electronics Engineers. 102(5). DOI: 10.1109/JPROC.2014.2314297

Jadi, M.P., Sejnowski, T.J. Cortical oscillations arise from contextual interactions that regulate sparse coding. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(18):6780-5. DOI: 10.1073/pnas.1405300111

McDonnell, M.D., Boahen, K., Ijspeert, A., Sejnowski, T.J. Engineering Intelligent Electronic Systems Based on Computational Neuroscience. (2014) Proceedings of the IEEE. Institute of Electrical and Electronics Engineers. 102(5):646-651. DOI: 10.1109/JPROC.2014.2314776

Jadi, M.P., Sejnowski, T.J. Regulating Cortical Oscillations in an Inhibition-Stabilized Network. (2014) Proceedings of the IEEE. Institute of Electrical and Electronics Engineers. 102(5). DOI: 10.1109/JPROC.2014.2313113

Edwards, J., Daniel, E., Kinney, J., Bartol, T., Sejnowski, T. , Johnston, D., Harris, K., Bajaj, C. VolRoverN: enhancing surface and volumetric reconstruction for realistic dynamical simulation of cellular and subcellular function. (2014) Neuroinformatics. 12(2):277-89. DOI: 10.1007/s12021-013-9205-2

Lainscsek, C., Weyhenmeyer, J., Hernandez, M.E., Poizner, H., Sejnowski, T.J. Non-linear dynamical classification of short time series of the rössler system in high noise regimes. (2013) Frontiers in Neurology. 4:182. DOI: 10.3389/fneur.2013.00182

Lainscsek, C., Hernandez, M.E., Weyhenmeyer, J., Sejnowski, T.J. , Poizner, H. Non-linear dynamical analysis of EEG time series distinguishes patients with Parkinson's disease from healthy individuals. (2013) Frontiers in Neurology. 4:200. DOI: 10.3389/fneur.2013.00200

Cortes, J.M., Desroches, M., Rodrigues, S., Veltz, R., Muñoz, M.A., Sejnowski, T.J. Short-term synaptic plasticity in the deterministic Tsodyks-Markram model leads to unpredictable network dynamics. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(41):16610-5. DOI: 10.1073/pnas.1316071110

Timofeev, I., Sejnowski, T.J. , Bazhenov, M., Chauvette, S., Grand, L.B. Age dependency of trauma-induced neocortical epileptogenesis. (2013) Frontiers in Cellular Neuroscience. 7:154. DOI: 10.3389/fncel.2013.00154

Lister, R.*, Mukamel, E.A., Nery, J.R., Urich, M., Puddifoot, C.A., Johnson, N.D., Lucero, J., Huang, Y., Dwork, A.J., Schultz, M.D., Yu, M., Tonti-Filippini, J., Heyn, H., Hu, S., Wu, J.C., Rao, A., Esteller, M., He, C., Haghighi, F.G., Sejnowski, T.J. , Behrens, M.M.*, Ecker, J.R.* Global epigenomic reconfiguration during mammalian brain development. (2013) Science. 341(6146):1237905. DOI: 10.1126/science.1237905

Golomb, B.A., Brenner, S., Chalfie, M., Glashow, S.L., Glauber, R.J., Hubel, D.H., Maskin, E.S., Greengard, P., Gross, D.J., Roberts, R., Tonegawa, S., Wilczek, F.A., Brown, E.M., Sejnowski, T.J. Chocolate habits of Nobel prizewinners. (2013) Nature. 499(7459):409. DOI: 10.1038/499409a

Ji, B., Wang, X., Pinto-Duarte, A., Kim, M., Caldwell, S., Young, J.W., Behrens, M.M., Sejnowski, T.J. , Geyer, M.A., Zhou, X. Prolonged Ketamine Effects in Sp4 Hypomorphic Mice: Mimicking Phenotypes of Schizophrenia. (2013) PLOS One. 8(6):e66327. DOI: 10.1371/journal.pone.0066327

Chukoskie, L., Snider, J., Mozer, M.C., Krauzlis, R.J., Sejnowski, T.J. Learning where to look for a hidden target. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110 Suppl :10438-45. DOI: 10.1073/pnas.1301216110

Stiefel, K.M., Englitz, B., Sejnowski, T.J. Origin of intrinsic irregular firing in cortical interneurons. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(19):7886-91. DOI: 10.1073/pnas.1305219110

Gire, D.H., Restrepo, D., Sejnowski, T.J. , Greer, C., De Carlos, J.A., Lopez-Mascaraque, L. Temporal processing in the olfactory system: can we see a smell? (2013) Neuron. 78(3):416-32. DOI: 10.1016/j.neuron.2013.04.033

Wang, X., Pinto-Duarte, A., Sejnowski, T.J. , Behrens, M.M. How Nox2-containing NADPH oxidase affects cortical circuits in the NMDA receptor antagonist model of schizophrenia. (2013) Antioxidants & Redox Signaling. 18(12):1444-62. DOI: 10.1089/ars.2012.4907

Regner, B.M., Vučinić, D., Domnisoru, C., Bartol, T.M., Hetzer, M.W., Tartakovsky, D.M., Sejnowski, T.J. Anomalous diffusion of single particles in cytoplasm. (2013) Biophysical Journal. 104(8):1652-60. DOI: 10.1016/j.bpj.2013.01.049

Alivisatos, A.P., Andrews, A.M., Boyden, E.S., Chun, M., Church, G.M., Deisseroth, K., Donoghue, J.P., Fraser, S.E., Lippincott-Schwartz, J., Looger, L.L., Masmanidis, S., McEuen, P.L., Nurmikko, A.V., Park, H., Peterka, D.S., Reid, C., Roukes, M.L., Scherer, A., Schnitzer, M., Sejnowski, T.J. , Shepard, K.L., Tsao, D., Turrigiano, G., Weiss, P.S., Xu, C., Yuste, R., Zhuang, X. Nanotools for neuroscience and brain activity mapping. (2013) ACS Nano. 7(3):1850-66. DOI: 10.1021/nn4012847

Alivisatos, A.P., Chun, M., Church, G.M., Deisseroth, K., Donoghue, J.P., Greenspan, R.J., McEuen, P.L., Roukes, M.L., Sejnowski, T.J. , Weiss, P.S., Yuste, R. Neuroscience. The brain activity map. (2013) Science. 339(6125):1284-5. DOI: 10.1126/science.1236939

Saremi, S., Sejnowski, T.J. Hierarchical model of natural images and the origin of scale invariance. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(8):3071-6. DOI: 10.1073/pnas.1222618110

Tanaka, H., Sejnowski, T.J. Computing reaching dynamics in motor cortex with Cartesian spatial coordinates. (2013) Journal of Neurophysiology. 109(4):1182-201. DOI: 10.1152/jn.00279.2012

Kinney, J.P., Spacek, J., Bartol, T.M., Bajaj, C.L., Harris, K.M., Sejnowski, T.J. Extracellular sheets and tunnels modulate glutamate diffusion in hippocampal neuropil. (2013) Journal of Comparative Neurology. 521(2):448-64. DOI: 10.1002/cne.23181

Srinivasan, L., Asaad, W.F., Ginat, D.T., Gale, J.T., Dougherty, D.D., Williams, Z.M., Sejnowski, T.J. , Eskandar, E.N. Action initiation in the human dorsal anterior cingulate cortex. (2013) PLOS One. 8(2):e55247. DOI: 10.1371/journal.pone.0055247

Toups, J.V., Fellous, J.M., Thomas, P.J., Sejnowski, T.J. , Tiesinga, P.H. Multiple spike time patterns occur at bifurcation points of membrane potential dynamics. (2012) PLOS Computational Biology. 8(10):e1002615. DOI: 10.1371/journal.pcbi.1002615

Catterall, W.A., Raman, I.M., Robinson, H.P., Sejnowski, T.J. , Paulsen, O. The Hodgkin-Huxley heritage: from channels to circuits. (2012) Journal of Neuroscience. 32(41):14064-73. DOI: 10.1523/JNEUROSCI.3403-12.2012

Nadkarni, S., Bartol, T.M., Stevens, C.F., Sejnowski, T.J. , Levine, H. Short-term plasticity constrains spatial organization of a hippocampal presynaptic terminal. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(36):14657-62. DOI: 10.1073/pnas.1211971109

70 VDCCs located 300 nm from the active zone. This result is surprising, because structural studies on other synapses in the hippocampus report much tighter spatial coupling. We demonstrate that the unusual structure of this synapse reflects its functional role in short-term plasticity (STP).

Volman, V., Bazhenov, M., Sejnowski, T.J. Computational models of neuron-astrocyte interaction in epilepsy. (2012) Frontiers in Computational Neuroscience. 6:58. DOI: 10.3389/fncom.2012.00058

Bonjean, M., Baker, T., Bazhenov, M., Cash, S., Halgren, E., Sejnowski, T. Interactions between core and matrix thalamocortical projections in human sleep spindle synchronization. (2012) Journal of Neuroscience. 32(15):5250-63. DOI: 10.1523/JNEUROSCI.6141-11.2012

Tanaka, H., Krakauer, J.W., Sejnowski, T.J. Generalization and multirate models of motor adaptation. (2012) Neural Computation. 24(4):939-66. DOI: 10.1162/NECO_a_00262

Volman, V., Behrens, M.M., Sejnowski, T.J. Downregulation of parvalbumin at cortical GABA synapses reduces network gamma oscillatory activity. (2011) Journal of Neuroscience. 31(49):18137-48. DOI: 10.1523/JNEUROSCI.3041-11.2011

Wei, H., Bonjean, M., Petry, H.M., Sejnowski, T.J. , Bickford, M.E. Thalamic burst firing propensity: a comparison of the dorsal lateral geniculate and pulvinar nuclei in the tree shrew. (2011) Journal of Neuroscience. 31(47):17287-99. DOI: 10.1523/JNEUROSCI.6431-10.2011

Brenner, S., Sejnowski, T.J. Understanding the human brain. (2011) Science. 334(6056):567. DOI: 10.1126/science.1215674

Volman, V., Sejnowski, T.J. , Bazhenov, M. Topological basis of epileptogenesis in a model of severe cortical trauma. (2011) Journal of Neurophysiology. 106(4):1933-42. DOI: 10.1152/jn.00458.2011

Yu, T., Sejnowski, T.J. , Cauwenberghs, G. Biophysical Neural Spiking, Bursting, and Excitability Dynamics in Reconfigurable Analog VLSI. (2011) IEEE Trans Biomed Circuits Syst. 5(5):420-9. DOI: 10.1109/TBCAS.2011.2169794

Volman, V., Bazhenov, M., Sejnowski, T.J. Pattern of trauma determines the threshold for epileptic activity in a model of cortical deafferentation. (2011) Proceedings of the National Academy of Sciences of the United States of America. 108(37):15402-7. DOI: 10.1073/pnas.1112066108

Dang-Vu, T.T., Bonjean, M., Schabus, M., Boly, M., Darsaud, A., Desseilles, M., Degueldre, C., Balteau, E., Phillips, C., Luxen, A., Sejnowski, T.J. , Maquet, P. Interplay between spontaneous and induced brain activity during human non-rapid eye movement sleep. (2011) Proceedings of the National Academy of Sciences of the United States of America. 108(37):15438-43. DOI: 10.1073/pnas.1112503108

Toups, J.V., Fellous, J.M., Thomas, P.J., Sejnowski, T.J. , Tiesinga, P.H. Finding the event structure of neuronal spike trains. (2011) Neural Computation. 23(9):2169-208. DOI: 10.1162/NECO_a_00173

Bonjean, M., Baker, T., Lemieux, M., Timofeev, I., Sejnowski, T. , Bazhenov, M. Corticothalamic feedback controls sleep spindle duration in vivo. (2011) Journal of Neuroscience. 31(25):9124-34. DOI: 10.1523/JNEUROSCI.0077-11.2011

Romani, S., Sejnowski, T.J. , Tsodyks, M. Intracellular dynamics of virtual place cells. (2011) Neural Computation. 23(3):651-5. DOI: 10.1162/NECO_a_00087

Peterson, D.A., Lotz, D.T., Halgren, E., Sejnowski, T.J. , Poizner, H. Choice modulates the neural dynamics of prediction error processing during rewarded learning. (2011) Neuroimage. 54(2):1385-94. DOI: 10.1016/j.neuroimage.2010.09.051

Timofeev, I., Bazhenov, M., Seigneur, J., Sejnowski, T. Neocortical synchronization. (2010) Epilepsia. 51(Suppl 5):18. DOI: 10.1111/j.1528-1167.2010.02804.x

Hill, E.S., Moore-Kochlacs, C., Vasireddi, S.K., Sejnowski, T.J. , Frost, W.N. Validation of independent component analysis for rapid spike sorting of optical recording data. (2010) Journal of Neurophysiology. 104(6):3721-31. DOI: 10.1152/jn.00691.2010

Sejnowski, T.J. Learning optimal strategies in complex environments. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(47):20151-2. DOI: 10.1073/pnas.1014954107

Coggan, J.S., Prescott, S.A., Bartol, T.M., Sejnowski, T.J. Imbalance of ionic conductances contributes to diverse symptoms of demyelination. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(48):20602-9. DOI: 10.1073/pnas.1013798107

Tiesinga, P.H., Sejnowski, T.J. Mechanisms for Phase Shifting in Cortical Networks and their Role in Communication through Coherence. (2010) Frontiers in Human Neuroscience. 4:196. DOI: 10.3389/fnhum.2010.00196

Nadkarni, S., Bartol, T.M., Sejnowski, T.J. , Levine, H. Modelling vesicular release at hippocampal synapses. (2010) PLOS Computational Biology. 6(11):e1000983. DOI: 10.1371/journal.pcbi.1000983

Sejnowski, T.J. QnAs with Terrence J. Sejnowski. [Interviewed by Prashant Nair]. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(48):20601. DOI: 10.1073/pnas.1015459107

Miller, K.J., Hermes, D., Honey, C.J., Sharma, M., Rao, R.P., den Nijs, M., Fetz, E.E., Sejnowski, T.J. , Hebb, A.O., Ojemann, J.G., Makeig, S., Leuthardt, E.C. Dynamic modulation of local population activity by rhythm phase in human occipital cortex during a visual search task. (2010) Frontiers in Human Neuroscience. 4:197. DOI: 10.3389/fnhum.2010.00197

Hao, J., Lee, T.W., Sejnowski, T.J. Speech Enhancement Using Gaussian Scale Mixture Models. (2010) IEEE Trans Audio Speech Lang Process. 18(6):1127-1136. DOI: 10.1109/TASL.2009.2030012

Fröhlich, F., Sejnowski, T.J. , Bazhenov, M. Network bistability mediates spontaneous transitions between normal and pathological brain states. (2010) Journal of Neuroscience. 30(32):10734-43. DOI: 10.1523/JNEUROSCI.1239-10.2010

Hasenstaub, A., Otte, S., Callaway, E., Sejnowski, T.J. Metabolic cost as a unifying principle governing neuronal biophysics. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(27):12329-34. DOI: 10.1073/pnas.0914886107

Nelson, J.D., McKenzie, C.R., Cottrell, G.W., Sejnowski, T.J. Experience matters: information acquisition optimizes probability gain. (2010) Psychol Sci. 21(7):960-9. DOI: 10.1177/0956797610372637

Hao, J., Lee, I., Lee, T.W., Sejnowski, T.J. Independent vector analysis for source separation using a mixture of gaussians prior. (2010) Neural Computation. 22(6):1646-73. DOI: 10.1162/neco.2010.11-08-906

Moldakarimov, S., Bazhenov, M., Sejnowski, T.J. Representation sharpening can explain perceptual priming. (2010) Neural Computation. 22(5):1312-32. DOI: 10.1162/neco.2009.04-09-999

Modchang, C., Nadkarni, S., Bartol, T.M., Triampo, W., Sejnowski, T.J. , Levine, H., Rappel, W.J. A comparison of deterministic and stochastic simulations of neuronal vesicle release models. (2010) Phys Biol. 7(2):026008. DOI: 10.1088/1478-3975/7/2/026008

Wang, H.P., Spencer, D., Fellous, J.M., Sejnowski, T.J. Synchrony of thalamocortical inputs maximizes cortical reliability. (2010) Science. 328(5974):106-9. DOI: 10.1126/science.1183108

Stiefel, K.M., Fellous, J.M., Thomas, P.J., Sejnowski, T.J. Intrinsic subthreshold oscillations extend the influence of inhibitory synaptic inputs on cortical pyramidal neurons. (2010) European Journal of Neuroscience. 31(6):1019-26. DOI: 10.1111/j.1460-9568.2010.07146.x

Moldakarimov, S., Bazhenov, M., Sejnowski, T.J. Perceptual priming leads to reduction of gamma frequency oscillations. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(12):5640-5. DOI: 10.1073/pnas.0907525107

Drion, G., Bonjean, M., Waroux, O., Scuvée-Moreau, J., Liégeois, J.F., Sejnowski, T.J. , Sepulchre, R., Seutin, V. M-type channels selectively control bursting in rat dopaminergic neurons. (2010) European Journal of Neuroscience. 31(5):827-35. DOI: 10.1111/j.1460-9568.2010.07107.x

Peterson, D.A., Sejnowski, T.J. , Poizner, H. Convergent evidence for abnormal striatal synaptic plasticity in dystonia. (2010) Neurobiol. Dis. 37(3):558-73. DOI: 10.1016/j.nbd.2009.12.003

Sejnowski, T.J. Consequences of non-uniform active currents in dendrites. (2009) Frontiers in Neuroscience. 3(3):332-3. DOI: 10.3389/neuro.01.038.2009

Volman, V., Levine, H., Ben-Jacob, E., Sejnowski, T.J. Locally balanced dendritic integration by short-term synaptic plasticity and active dendritic conductances. (2009) Journal of Neurophysiology. 102(6):3234-50. DOI: 10.1152/jn.00260.2009

Peterson, D.A., Elliott, C., Song, D.D., Makeig, S., Sejnowski, T.J. , Poizner, H. Probabilistic reversal learning is impaired in Parkinson's disease. (2009) Neuroscience. 163(4):1092-101. DOI: 10.1016/j.neuroscience.2009.07.033

Conner, J.M., Franks, K.M., Titterness, A.K., Russell, K., Merrill, D.A., Christie, B.R., Sejnowski, T.J. , Tuszynski, M.H. NGF is essential for hippocampal plasticity and learning. (2009) Journal of Neuroscience. 29(35):10883-9. DOI: 10.1523/JNEUROSCI.2594-09.2009

Makeig, S., Gramann, K., Jung, T.P., Sejnowski, T.J. , Poizner, H. Linking brain, mind and behavior. (2009) Int J Psychophysiol. 73(2):95-100. DOI: 10.1016/j.ijpsycho.2008.11.008

Destexhe, A., Sejnowski, T.J. The Wilson-Cowan model, 36 years later. (2009) Biol Cybern. 101(1):1-2. DOI: 10.1007/s00422-009-0328-3

Meltzoff, A.N., Kuhl, P.K., Movellan, J., Sejnowski, T.J. Foundations for a new science of learning. (2009) Science. 325(5938):284-8. DOI: 10.1126/science.1175626

Stiefel, K.M., Gutkin, B.S., Sejnowski, T.J. The effects of cholinergic neuromodulation on neuronal phase-response curves of modeled cortical neurons. (2009) Journal of Computational Neuroscience. 26(2):289-301. DOI: 10.1007/s10827-008-0111-9

Schwartz, O., Sejnowski, T.J. , Dayan, P. Perceptual organization in the tilt illusion. (2009) Journal of Vision. 9(4):19.1-20. DOI: 10.1167/9.4.19

Bazhenov, M., Timofeev, I., Fröhlich, F., Sejnowski, T.J. Cellular and network mechanisms of electrographic seizures. (2009) Drug Discov Today Dis Models. 5(1):45-57. DOI: 10.1016/j.ddmod.2008.07.005

Hao, J., Attias, H., Nagarajan, S., Lee, T.W., Sejnowski, T.J. Speech Enhancement, Gain, and Noise Spectrum Adaptation Using Approximate Bayesian Estimation. (2009) IEEE Trans Audio Speech Lang Process. 17(1):24-37. DOI: 10.1109/TASL.2008.2005342

Prescott, S.A., Ratté, S., De Koninck, Y., Sejnowski, T.J. Pyramidal neurons switch from integrators in vitro to resonators under in vivo-like conditions. (2008) Journal of Neurophysiology. 100(6):3030-42. DOI: 10.1152/jn.90634.2008

Fröhlich, F., Bazhenov, M., Iragui-Madoz, V., Sejnowski, T.J. Potassium dynamics in the epileptic cortex: new insights on an old topic. (2008) The Neuroscientist. 14(5):422-33. DOI: 10.1177/1073858408317955

Kerr, R.A., Bartol, T.M., Kaminsky, B., Dittrich, M., Chang, J.C., Baden, S.B., Sejnowski, T.J. , Stiles, J.R. FAST MONTE CARLO SIMULATION METHODS FOR BIOLOGICAL REACTION-DIFFUSION SYSTEMS IN SOLUTION AND ON SURFACES. (2008) SIAM Journal on Scientific Computing. 30(6):3126. DOI: 10.1137/070692017

Prescott, S.A., De Koninck, Y., Sejnowski, T.J. Biophysical basis for three distinct dynamical mechanisms of action potential initiation. (2008) PLOS Computational Biology. 4(10):e1000198. DOI: 10.1371/journal.pcbi.1000198

Lopreore, C.L., Bartol, T.M., Coggan, J.S., Keller, D.X., Sosinsky, G.E., Ellisman, M.H., Sejnowski, T.J. Computational modeling of three-dimensional electrodiffusion in biological systems: application to the node of Ranvier. (2008) Biophysical Journal. 95(6):2624-35. DOI: 10.1529/biophysj.108.132167

Low, P.S., Shank, S.S., Sejnowski, T.J. , Margoliash, D. Mammalian-like features of sleep structure in zebra finches. (2008) Proceedings of the National Academy of Sciences of the United States of America. 105(26):9081-6. DOI: 10.1073/pnas.0703452105

Keller, D.X., Franks, K.M., Bartol, T.M., Sejnowski, T.J. Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines. (2008) PLOS One. 3(4):e2045. DOI: 10.1371/journal.pone.0002045

Finelli, L.A., Haney, S., Bazhenov, M., Stopfer, M., Sejnowski, T.J. Synaptic learning rules and sparse coding in a model sensory system. (2008) PLOS Computational Biology. 4(4):e1000062. DOI: 10.1371/journal.pcbi.1000062

Fröhlich, F., Bazhenov, M., Sejnowski, T.J. Pathological effect of homeostatic synaptic scaling on network dynamics in diseases of the cortex. (2008) Journal of Neuroscience. 28(7):1709-20. DOI: 10.1523/JNEUROSCI.4263-07.2008

Chen, E., Stiefel, K.M., Sejnowski, T.J. , Bullock, T.H. Model of traveling waves in a coral nerve network. (2008) J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 194(2):195-200. DOI: 10.1007/s00359-007-0305-z

Tiesinga, P., Fellous, J.M., Sejnowski, T.J. Regulation of spike timing in visual cortical circuits. (2008) Nature Reviews. Neuroscience. 9(2):97-107. DOI: 10.1038/nrn2315

Tour, O., Adams, S.R., Kerr, R.A., Meijer, R.M., Sejnowski, T.J. , Tsien, R.W., Tsien, R.Y. Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator. (2007) Nature Chemical Biology. 3(7):423-31. DOI: 10.1038/nchembio.2007.4

Mishra, J., Martinez, A., Sejnowski, T.J. , Hillyard, S.A. Early cross-modal interactions in auditory and visual cortex underlie a sound-induced visual illusion. (2007) Journal of Neuroscience. 27(15):4120-31. DOI: 10.1523/JNEUROSCI.4912-06.2007

Schwartz, O., Sejnowski, T.J. , Dayan, P. Soft mixer assignment in a hierarchical generative model of natural scene statistics. (2006) Neural Computation. 18(11):2680-718. DOI: 10.1162/neco.2006.18.11.2680

Anemüller, J., Duann, J.R., Sejnowski, T.J. , Makeig, S. Spatio-temporal dynamics in fMRI recordings revealed with complex independent component analysis. (2006) Neurocomputing. 69(13-15):1502-1512. DOI: 10.1016/j.neucom.2005.12.029

Fröhlich, F., Bazhenov, M., Timofeev, I., Steriade, M., Sejnowski, T.J. Slow state transitions of sustained neural oscillations by activity-dependent modulation of intrinsic excitability. (2006) Journal of Neuroscience. 26(23):6153-62. DOI: 10.1523/JNEUROSCI.5509-05.2006

Sejnowski, T.J. , Paulsen, O. Network oscillations: emerging computational principles. (2006) Journal of Neuroscience. 26(6):1673-6. DOI: 10.1523/JNEUROSCI.3737-05d.2006

Kerr, R.A., Levine, H., Sejnowski, T.J. , Rappel, W.J. Division accuracy in a stochastic model of Min oscillations in Escherichia coli. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(2):347-52. DOI: 10.1073/pnas.0505825102

Sample, P.A., Boden, C., Zhang, Z., Pascual, J., Lee, T.W., Zangwill, L.M., Weinreb, R.N., Crowston, J.G., Hoffmann, E.M., Medeiros, F.A., Sejnowski, T. , Goldbaum, M. Unsupervised machine learning with independent component analysis to identify areas of progression in glaucomatous visual fields. (2005) Investigative Ophthalmology & Visual Science. 46(10):3684-92. DOI: 10.1167/iovs.04-1168

Goldbaum, M.H., Sample, P.A., Zhang, Z., Chan, K., Hao, J., Lee, T.W., Boden, C., Bowd, C., Bourne, R., Zangwill, L., Sejnowski, T. , Spinak, D., Weinreb, R.N. Using unsupervised learning with independent component analysis to identify patterns of glaucomatous visual field defects. (2005) Investigative Ophthalmology & Visual Science. 46(10):3676-83. DOI: 10.1167/iovs.04-1167

Gillette, M.U., Sejnowski, T.J. Physiology. Biological clocks coordinately keep life on time. (2005) Science. 309(5738):1196-8. DOI: 10.1126/science.1111420

Prank, K., Schulze, E., Eckert, O., Nattkemper, T.W., Bettendorf, M., Maser-Gluth, C., Sejnowski, T.J. , Grote, A., Penner, E., von Zur Mühlen, A., Brabant, G. Machine learning approaches for phenotype-genotype mapping: predicting heterozygous mutations in the CYP21B gene from steroid profiles. (2005) Eur. J. Endocrinol. 153(2):301-5. DOI: 10.1530/eje.1.01957

Coggan, J.S., Bartol, T.M., Esquenazi, E., Stiles, J.R., Lamont, S., Martone, M.E., Berg, D.K., Ellisman, M.H., Sejnowski, T.J. Evidence for ectopic neurotransmission at a neuronal synapse. (2005) Science. 309(5733):446-51. DOI: 10.1126/science.1108239

Houweling, A.R., Bazhenov, M., Timofeev, I., Steriade, M., Sejnowski, T.J. Homeostatic synaptic plasticity can explain post-traumatic epileptogenesis in chronically isolated neocortex. (2005) Cerebral Cortex . 15(6):834-45. DOI: 10.1093/cercor/bhh184

Bazhenov, M., Stopfer, M., Sejnowski, T.J. , Laurent, G. Fast odor learning improves reliability of odor responses in the locust antennal lobe. (2005) Neuron. 46(3):483-92. DOI: 10.1016/j.neuron.2005.03.022

Duann, J.R., Jung, T.P., Makeig, S., Sejnowski, T. Repeated decompositions reveal the stability of infomax decomposition of fMRI data. (2005) Conf Proc IEEE Eng Med Biol Soc. 5:5324-7. DOI: 10.1109/IEMBS.2005.1615683

Bowd, C., Medeiros, F.A., Zhang, Z., Zangwill, L.M., Hao, J., Lee, T.W., Sejnowski, T.J. , Weinreb, R.N., Goldbaum, M.H. Relevance vector machine and support vector machine classifier analysis of scanning laser polarimetry retinal nerve fiber layer measurements. (2005) Investigative Ophthalmology & Visual Science. 46(4):1322-9. DOI: 10.1167/iovs.04-1122

Lehky, S.R., Sejnowski, T.J. , Desimone, R. Selectivity and sparseness in the responses of striate complex cells. (2005) Vision Research. 45(1):57-73. DOI: 10.1016/j.visres.2004.07.021

Fuentealba, P., Timofeev, I., Bazhenov, M., Sejnowski, T.J. , Steriade, M. Membrane bistability in thalamic reticular neurons during spindle oscillations. (2005) Journal of Neurophysiology. 93(1):294-304. DOI: 10.1152/jn.00552.2004

Sejnowski, T.J. In memoriam: Francis H.C. Crick. (2004) Neuron. 43(5):619-21. DOI: 10.1016/j.neuron.2004.08.022

Zangwill, L.M., Chan, K., Bowd, C., Hao, J., Lee, T.W., Weinreb, R.N., Sejnowski, T.J. , Goldbaum, M.H. Heidelberg retina tomograph measurements of the optic disc and parapapillary retina for detecting glaucoma analyzed by machine learning classifiers. (2004) Investigative Ophthalmology & Visual Science. 45(9):3144-51. DOI: 10.1167/iovs.04-0202

Bazhenov, M., Timofeev, I., Steriade, M., Sejnowski, T.J. Potassium model for slow (2-3 Hz) in vivo neocortical paroxysmal oscillations. (2004) Journal of Neurophysiology. 92(2):1116-32. DOI: 10.1152/jn.00529.2003

Sample, P.A., Chan, K., Boden, C., Lee, T.W., Blumenthal, E.Z., Weinreb, R.N., Bernd, A., Pascual, J., Hao, J., Sejnowski, T. , Goldbaum, M.H. Using unsupervised learning with variational bayesian mixture of factor analysis to identify patterns of glaucomatous visual field defects. (2004) Investigative Ophthalmology & Visual Science. 45(8):2596-605. DOI: 10.1167/iovs.03-0343

Tiesinga, P.H., Fellous, J.M., Salinas, E., José, J.V., Sejnowski, T.J. Inhibitory synchrony as a mechanism for attentional gain modulation. (2004) Journal of Physiology, Paris. 98(4-6):296-314. DOI: 10.1016/j.jphysparis.2005.09.002

Fuentealba, P., Crochet, S., Timofeev, I., Bazhenov, M., Sejnowski, T.J. , Steriade, M. Experimental evidence and modeling studies support a synchronizing role for electrical coupling in the cat thalamic reticular neurons in vivo. (2004) European Journal of Neuroscience. 20(1):111-9. DOI: 10.1111/j.1460-9568.2004.03462.x

Bowd, C., Zangwill, L.M., Medeiros, F.A., Hao, J., Chan, K., Lee, T.W., Sejnowski, T.J. , Goldbaum, M.H., Sample, P.A., Crowston, J.G., Weinreb, R.N. Confocal scanning laser ophthalmoscopy classifiers and stereophotograph evaluation for prediction of visual field abnormalities in glaucoma-suspect eyes. (2004) Investigative Ophthalmology & Visual Science. 45(7):2255-62.

Schwartz, O., Movellan, J.R., Wachtler, T., Albright, T.D., Sejnowski, T.J. Spike count distributions, factorizability, and contextual effects in area V1. (2004) Neurocomputing. 58-60:893-900. DOI: 10.1016/j.neucom.2004.01.143

Arnold, M., Sejnowski, T. , Hammerstrom, D., Jabri, M. Neural systems integration. (2004) Neurocomputing. 58-60:1123-1128. DOI: 10.1016/j.neucom.2004.01.176

Makeig, S., Delorme, A., Westerfield, M., Jung, T.P., Townsend, J., Courchesne, E., Sejnowski, T.J. Electroencephalographic brain dynamics following manually responded visual targets. (2004) PLOS Biology. 2(6):e176. DOI: 10.1371/journal.pbio.0020176

Tiesinga, P.H., Fellous, J.M., Salinas, E., José, J.V., Sejnowski, T.J. Synchronization as a mechanism for attentional gain modulation. (2004) Neurocomputing. 58-60:641-646. DOI: 10.1016/j.neucom.2004.01.108

Eagleman, D.M., Jacobson, J.E., Sejnowski, T.J. Perceived luminance depends on temporal context. (2004) Nature. 428(6985):854-6. DOI: 10.1038/nature02467

Fellous, J.M., Tiesinga, P.H., Thomas, P.J., Sejnowski, T.J. Discovering spike patterns in neuronal responses. (2004) Journal of Neuroscience. 24(12):2989-3001. DOI: 10.1523/JNEUROSCI.4649-03.2004

Tiesinga, P.H., Sejnowski, T.J. Rapid temporal modulation of synchrony by competition in cortical interneuron networks. (2004) Neural Computation. 16(2):251-75. DOI: 10.1162/089976604322742029

Schreiber, S., Fellous, J.M., Tiesinga, P., Sejnowski, T.J. Influence of ionic conductances on spike timing reliability of cortical neurons for suprathreshold rhythmic inputs. (2004) Journal of Neurophysiology. 91(1):194-205. DOI: 10.1152/jn.00556.2003

Anemüller, J., Sejnowski, T.J. , Makeig, S. Complex independent component analysis of frequency-domain electroencephalographic data. (2003) Neural Networks. 16(9):1311-23. DOI: 10.1016/j.neunet.2003.08.003

Sejnowski, T. The computational self. (2003) Ann. N. Y. Acad. Sci. 1001:262-71.

Laughlin, S.B., Sejnowski, T.J. Communication in neuronal networks. (2003) Science. 301(5641):1870-4. DOI: 10.1126/science.1089662

Sejnowski, T.J. Perceptions of science. Tap into science 24-7. (2003) Science. 301(5633):601. DOI: 10.1126/science.1084463

Kretzberg, J., Sejnowski, T. , Warzecha, A.K., Egelhaaf, M. Variability of postsynaptic responses depends non-linearly on the number of synaptic inputs. (2003) Neurocomputing. 52-54:313-320. DOI: 10.1016/S0925-2312(02)00797-X

Schreiber, S., Fellous, J.M., Whitmer, D., Tiesinga, P., Sejnowski, T.J. A new correlation-based measure of spike timing reliability. (2003) Neurocomputing. 52-54:925-931. DOI: 10.1016/S0925-2312(02)00838-X

Rao, R.P., Sejnowski, T.J. Self-organizing neural systems based on predictive learning. (2003) Philos Trans A Math Phys Eng Sci. 361(1807):1149-75. DOI: 10.1098/rsta.2003.1190

Thomas, P.J., Tiesinga, P.H., Fellous, J.M., Sejnowski, T.J. Reliability and bifurcation in neurons driven by multiple sinusoids. (2003) Neurocomputing. 52-54:955-961. DOI: 10.1016/S0925-2312(02)00856-1

Neubig, M., Destexhe, A., Sejnowski, T.J. Variability of quantal synaptic currents in thalamocortical neurons. (2003) Thalamus Relat Syst. 2(2):153-168. DOI: 10.1016/S1472-9288(03)00008-6

Kreutz-Delgado, K., Murray, J.F., Rao, B.D., Engan, K., Lee, T.W., Sejnowski, T.J. Dictionary learning algorithms for sparse representation. (2003) Neural Computation. 15(2):349-96. DOI: 10.1162/089976603762552951

Franks, K.M., Sejnowski, T.J. Complexity of calcium signaling in synaptic spines. (2002) BioEssays. 24(12):1130-44. DOI: 10.1002/bies.10193

Destexhe, A., Sejnowski, T.J. The initiation of bursts in thalamic neurons and the cortical control of thalamic sensitivity. (2002) Philos. Trans. R. Soc. Lond., B, Biol. Sci. 357(1428):1649-57. DOI: 10.1098/rstb.2002.1154

Bartlett, M.S., Movellan, J.R., Sejnowski, T.J. Face recognition by independent component analysis. (2002) IEEE Trans Neural Netw. 13(6):1450-64. DOI: 10.1109/TNN.2002.804287

Franks, K.M., Bartol, T.M., Sejnowski, T.J. A Monte Carlo model reveals independent signaling at central glutamatergic synapses. (2002) Biophysical Journal. 83(5):2333-48. DOI: 10.1016/S0006-3495(02)75248-X

Bazhenov, M., Timofeev, I., Steriade, M., Sejnowski, T.J. Model of thalamocortical slow-wave sleep oscillations and transitions to activated States. (2002) Journal of Neuroscience. 22(19):8691-704.

Salinas, E., Sejnowski, T.J. Integrate-and-fire neurons driven by correlated stochastic input. (2002) Neural Computation. 14(9):2111-55. DOI: 10.1162/089976602320264024

Sample, P.A., Goldbaum, M.H., Chan, K., Boden, C., Lee, T.W., Vasile, C., Boehm, A.G., Sejnowski, T. , Johnson, C.A., Weinreb, R.N. Using machine learning classifiers to identify glaucomatous change earlier in standard visual fields. (2002) Investigative Ophthalmology & Visual Science. 43(8):2660-5.

Houweling, A.R., Bazhenov, M., Timofeev, I., Grenier, F., Steriade, M., Sejnowski, T.J. Frequency-selective augmenting responses by short-term synaptic depression in cat neocortex. (2002) Journal of Physiology. 542(Pt 2):599-617.

Tiesinga, P.H., Fellous, J.M., Sejnowski, T.J. Attractor reliability reveals deterministic structure in neuronal spike trains. (2002) Neural Computation. 14(7):1629-50. DOI: 10.1162/08997660260028647

Timofeev, I., Bazhenov, M., Sejnowski, T. , Steriade, M. Cortical hyperpolarization-activated depolarizing current takes part in the generation of focal paroxysmal activities. (2002) Proceedings of the National Academy of Sciences of the United States of America. 99(14):9533-7. DOI: 10.1073/pnas.132259899